Multiple Choice Questions

1.  Tetracycline tend to form complexes with:

a. Calcium ions       b. Magnesium ions     c. Iron ions      d. Aluminum ions     e. All  

2. Hyaluronidase has been used as an adjunct to:

a. Prevents oxidation of drugs         b. Increase absorption of the injected drugs

c. Produce sustained action             d. Increase detoxification  

3. Which of the following compound of undecylenic acid is most commonly used in therapy:

a. Zinc         b. Magnesium     c. Manganese         d.  Silver     

4.  An oral antifungal agent is which of the following:

a. Sopronol       b. Desenex       c. Undecylenic acid       d. Griseofulvin 

5. Nitrofurantoin is most active when the pH of the urinary tract is:

a. Neutral        b. Over 9.5      c. Between 6 to 7       d. 5.5 or less 

6. Aloes are used to treat which of the following:

a. Burns     b. Gastritis      c. Carcinomas       d.  Vertigo 

7. Which of the following can  cause discoloration of teeth:

a. Chloromycetin       b. Penicillin       c. Achromycin       d. Kanamycin  

8. Which of the following can increase the serum level of penicillin significantly:

a. Salicylates       b. Probenecid        c. Kaolin       d.  Antacids  

9.  Which of the following diuretics is quite effective even in presence of electrolyte imbalance:

a. Ethacrynic acid      b. Ammonium Chloride      c. Chlorothiazide       d. Acetazolamide

10. Radioactive decay follows a:

a. Mixed order rate     b. Zero order rate     c. 1st order rate      d. IInd order rate 

11. A drug that reverses plasma- protein binding is often referred to as:

a. Protein hydrolysate      b. Displacer      c. Carrier substances      d.  Enzymes   

12. A rich source of Vitamin A is which of the following:

a. Lean meats      b. Liver     c. Poultry      d. Fish liver oils   

13. Methotrexate should never be used concurrently with:

a. Aspirin     b. Penicillin     c. Epinephrine      d.  Tetracycline  

14. An antidote for heparin overdosage is:

a. Protamine sulphate      b. Atropine       c. Calcium Salt     d.  Dicumerol 

15. AlCl3 is used mainly as which of the following:

a. Antiemetic       b. Antiperspirant       c. Urinary acidifier       d.  Laxatives

16. Which of the following may be used as plasma expanders:

a. Dextran      b. Na Salts      c. Starch     d. Calcium salts  

17. An antiemetic that contains principally carbohydrates derivatives is:

a. Emetrol       b. Vesprin     c. Compazine      d.  None  

18. Opium is obtained by which of the following:

a. Slitting capsule of a plant                         b. Extraction from leaves of a plant

c. Chemical synthesis                                    d. Grinding a plant

19. Chlorambucils acts primarily as a:

a. Antibiotics    b. Mitotic inhibitors   c. Alkylating agents    d. Antimetabolites 

20. For ophthalmic use, boric acid solutions should be:

a. Diluted with an equal volume of Sterile Distilled water   b. Diluted with an equal volume of isotonic saline solution

c. Diluted with an equal volume of Distilled water                d.  Undiluted

21. Salicyclic acid is used primarily as which of the following:

a. Analgesics      b. Antipyretics      c. Cough suppressant     d. Keratolytic agents   

22. Which of the following is an Expectorant agents:

a. Glyceryl guiacholate    b. Codeine   c. Wild cherry syrup     d.  Glycerine 

23. The most prevalent adverse reaction of selenium sulfide is:

a. Dryness of scalp   b. Irritation of skin    c. Discoloration of hair   d. Loss of hair 

24. A disadvantage of chloral hydrate is:

a. Lack of apsorption          b.  Rapid elimination 

c. Disagreeable odor          d. Allergic reaction  

25. Econazole nitrate (Spectazole) is most effective against:

a. Fungal infestations     b. Viruses     c. Rickettsia     d.  Tapeworm  

26. All tetracycline antibiotics:

a. Have same chemical structure but are stereotypic isomers    b. Are isolated from Streptococcus rinosus   

c. Produces same side effects                                              d. Are destroyed by alkali hydroxide

27. Aminocaproic acid is used to treat:

a. Warts     b. Hemorrhage      c. Hypertension       d. Protein loss  

28. The concentration of Nitrofurazone solution used ophthalmically is:

a. 2%      b. 20%      c. 0.02%     d. 1 %   

29. Dimethylsulphoxide is no longer used clinically because it was found to produce:

a. Agranulocytosis      b. Skin damage      c. Carcinomas      d. Eye  damage  

30.

30. Hetacillin is converted by the body to:

a. Ampicillin      b. Penicillin G     c. Penicillin V     d. Carbenicillin  

Correct Answer is:

1.

d. (All)
Tetracyclines tend to form complexes with Calcium ions, Magnesium ions, Iron ions and Aluminium ions etc.
Tetracyclines coordinate metal (II) ions under physiological conditions forming chelates complexes.

2.

b. (Increase absorption of the injected drugs)
Hyaluronidase has been used as an adjunct to increase absorption of injected drugs. - Hyaluronidase is given with other drugs by injection to break down hyaluronic acid helps make the fluids and connective tissue thinner so the drugs can move easily into the tissues.

3.

a. (Zinc)
Zinc is the compound of undecylenic acid, most commonly used in therapy.
Zinc undecylenate is a natural or synthetic fungistatic fatty acids, antifungal zinc undecylenate is used topically in creams against fungal infection, eczemas, ringworm, and other cutaneous conditions. The zinc provides an astringent action, reducing rawness and irritation.

4.

d. (Griseofulvin)
-An oral antifungal agent is Griseofulvin.
Griseofulvin is an antifungal medication used to treat a number of type of dermatophytosis, includes fungal infections of the nails and scalp, as well as the skin when the antifungal creams have not worked. It is taken by mouth.

5.

d. (5.5 or less)
Nitrofurantoin is most active when the pH of the urinary tract is acidic i.e. 5.5 or less.
Nitrofurantoin is an antibacterial medication used to treat urinary tract infections, but it is not as effective for kidney infections. It is taken by mouth. Common side effects includes nausea, loss od appetite, diarrhea, and headaches.
Nitrofurantoin is reduced by bacterial flavoprotein to reactives intermediate which inactivates or alter bacterial ribosomal proteins and other macromolecules.

6.

a. (Burns)
Aloes are used to treat burns.

Uses of aloes:

• It contains healthful plant compound
• It has antioxidant and antibacterial properties
• It accelerates wound healing
• It reduces dental plaque
• helps to treat canker sores
• reduces constipations
• improve skin and prevents wrinkles
• -lower blood sugar levels.
• Also used to treat burns.

  7.

c. (Achromycin)
Achromycin can cause discoloration of teeth.
Achromycin (Tetracycline antibiotics) used to treat bacterial infections, not work for viral infections.

8.

b. (Probenecid)
Probenecid can increase the serum levels of penicillin significantly. Since, Probenecid inhibits both the organic Anion Transporters in the basolateral membrane of cells in the proximal tubules, results in reduced clearance and increase plasma level of drugs normally secreted by this mechanism (Penicillin).
Note: Probenecid should not be used in the treatment of gout in conjunction with Salicylates because their therapeutics actions are antagonistic to each other.
Probenecid is used to treat chronic gout and gouty arthritis.

9.

a. (Ethacrynic acid)
Ethacrynic acid is quite effective even in presence of electrolyte imbalance. Actually, Ethacrynic acid belongs to “loop diuretics” group or water pills. Ethacrynic acid is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions.
Diuretics such as furosemide facilitates elimination of toxicants by altering their passive reabsorption from the tubular lumen. 

  10.

b. (Zero order rate)
Radioactive decays follows a zero order rate.
-Glucagon may be used as diagnostic agent in radio graphic examination of the GI tract.

Note:

• Mixed order kinetics: A mixture of both 1st and zero order kinetics in which deviation from an originally linear pharmacokinetics profile are observed, the rate process of such a drug is called as non- linear kinetics.
• Second order kinetics: A term describing the reaction rate of chemical reaction in which rate is proportional to the product of the concentration of two of the reactants or square of the molar concentration of the reactant if there is only one.

11.

a. (Protein hydrolysate)
Drug that reverses plasma- protein binding - protein hydrolysate
Plasma protein binding results in decrease availability of drug, while protein hydrolysate reverses plasma -protein binding leads to increase bioavailability of drug.

12.

d. (Fish liver oils)
Rich source of Vitamin A - Fish liver oils
Plasma level of vitamin- A is affected by Oral Contraceptives. Oral contraceptives markedly increases serum levels of Vitamin A. Decreases thiamine deficiency, also lower Riboflavin level and Ascorbic acid level.
Absorption of Vitamin A in GI tract depends on the presence of bile in the intestine.

13.

a. (Aspirin)
Methotrexate should never be used concurrently with Aspirin.
Methotrexate inhibits enzymes responsible for nucleotides synthesis including dihydrofolate reductase, thymidylate reductase, aminoimidazole caboxamide ribonucleotide transformylase, and amino phosphoribosyltransferase.
High dose aspirin plus methotrexate may increase kidney problems.
Methotrexate plus NSAIDS may cause a brief and mild increase in blood problems (Low platelets count).

14.

a. (Protamine sulphate)
An antidote for heparin overdosage - Protamine sulphate
In Overdose of heparin, the body is unable to deploy it’s natural defenses against hemorrhage (Excessive bleeding) and life- threatening blood loss can occurs quickly.
Antidote of Heparin Overdoses: Protamine sulphate. Protamine sulphate is highly cationic peptide that binds to either heparin or low molecular weight heparin to form stable ion pair. This complex is then removed and broken down by the reticuloendothelial system.
Anticoagulant acid citrate dextrose injection is required to be pyrogens free. Pyrogens are products that causes febrile reaction upon injection.

15.

b. (Antiperspirant)
AlCl3 is used as Antiperspirant.
Aluminium Chloride is used widely in manufacturing rubber, lubricants, wood preservatives and paints. It is used in pesticides and pharmaceuticals.
As a flux in Aluminium melting.
It is used as an antiperspirant.

16.

a. (Dextrans)
Dextrans may be used as plasma expanders.
Plasma Expanders: Plasma expanders are agents that have relatively high molecular weight and boost the plasma volume by increasing the osmotic pressure. They are used to treat patients who have suffered hemorrhage or shock.
Types of plasma expanders:
Cystalloids: Aqueous solution of mineral salts or other water soluble molecules. Ex: Normal saline, Dextrose and Ringer solutions.
Colloid: Colloids are large insoluble molecules such as Dextrans, Human albumin, Gelatin, Blood.

17.

a. (Emetrol)
An antiemetic that contains principally carbohydrates derivatives - Emetrol
Emetrol is the over the counter antiemetic drug contained phosphorylated carbohydrate used for the relief of nausea due to intestinal flu, stomach flu and food or drink indiscretions.

Note:

• Vesprin (Phenothiazines) are used to treat serious mental and emotional disorders including schizophrenia and other psychotic disorders.
• Compazine (Prochlorperazine) is a medication used to treat nausea, maigraine, schizophrenia, psychosis and anxiety.

18.

a. (Slitting capsule of a plant)
Opium is obtained by slitting capsules of a plant.
Opium, Narcotic drug that is obtained from the unripe seedpods of the opium poppy (Papaver somniferum), a plant of the family Papaveraceae. Opium is obtained by slightly incising the seed capsule of the poppy after the plant’s flower petals have fallen.

19.

c. (Alkylating agents)

• Chlorambucil acts as alkylating agent.
• Chlorambucil is an orally administered alkylating agents currently used in the therapy of chronic lymphocytic leukemia, Hodgkin and non- Hodgkin lymphomas, and rarely in severe autoimmune conditions including rheumatoid arthritis, uveitis and nephrotic syndrome.

20.

a. (Diluted with an equal volume of Sterile Distilled water)
For ophthalmic use, boric acid should be diluted with an equal volume of sterile distilled water.
Boric acid ophthalmic solution is an eye wash used to cleanse or irrigate eyes. Boric acid provides soothing relief from eye irritation and helps remove pollutant such as smog, chlorine or other chemicals.

21.

d. (Keratolytic agents)
Salicylic acid is used as Keratolytic agents.
Salicylic acid is belonged to the same class of drug as aspirin, works by increasing the amount of moisture in the skin and dissolving the substances that cause the skin cells to stick together, applied topically for the treatment of hyperkeratotic and scaling skin conditions such as dandruff and seborrheic dermatitis, ichthyosis, psoriasis, and acne.

22.

a. (Glyceryl guiacholate)

• Expectorants agents - Glyceryl guiacholate
• Guaifenesin, also known as glyceryl guaiacholate is an expectorant medication that aids in the elimination of sputum from the respiratory tract.
• Chemically, it is an ether of guaiacol and glycerine.

Note:

Codeine is a pain killer.

23.

b. (Irritation of skin)
Most prevalent adverse reaction of selenium sulfide - Irritation of skin
Selenium sulfide, an anti- infective agent, relieves itching, and flaking of the scalp and remove the dry, scaly particles that are commonly referred to as dandruff or seborrhea.
It is also used to treat tinea versicolor, a fungal infection of the skin.

24.

c. (Disagreable odour)
Disadvantage of Chloral hydrate - Disagreable odour
Chloral hydrate, a sedative is used in the short term treatment of insomnia, and to relieve anxiety and to induce sleep before surgery.
Also used after surgery for pain and to treat alcohol withdrawal.

25.

a. (Fungal infestations)

• Econazole nitrate (Spectazole) is most effective against Fungal infestations.  
• Econazole nitrate is an antifungal medication of imidazole class used to treat skin infections such as athlete’s foot, jock itch, and ringworm.
• Side effects of Econazole nitrate cream: Burning, itching, stinging, redness or other sign of irritation at the application site.

26.

d. (Are destroyed by alkali hydroxide)
All tetracycline antibiotics are destroyed by alkali hydroxide.

Facts related to Tetracycline:

• Tetracycline is yellow, odorless crystalline powder.
• It is stable in air, but exposure to strong sunlight causes it to darken.
• It’s potency is affected in solution of pH below 2 and is rapidly destroyed by alkali hydroxide solution.
• Tetracycline should not be taken with antacids because it forms insoluble complex molecules by metal ions chelation with various antacids; Tetracycline absorption may be decreased by more than 90% by this interaction.

27.

b. (Hemorrhage)

• Aminocaproic acid is used to treat hemorrhage.
• Aminocaproic acid, antifibrinolytic agent, is a medication used to manage and treat acute bleeding disorder.
• Aminocaproic acid is used in managing hyperfibrinolysis- induced hemorrhage.

28.

c. (0.02%)

• The concentration of Nitrofurazone solution used ophthalmically is 0.02%.
• Nitrofurazone is an antimicrobial organic compound belonging to nitrofuran class, used as a topical antibiotic ointment.
• It is effective against gram- positive bacteria, gram - negative bacteria and can be used in the treatment of trypanosomiasis.
• Nitrofurazone is used to treat burns that have become infected. Also used to treat skin infections due to skin graft.

29.

d. (Eye damage)

• Dimethylsulphoxide is no longer used clinically because it was found to produce eye damage.
• Dimethylsulphoxide is the Organo Sulphur compound, mostly used for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs.

30.

a. (Ampicillin)

• Hetacillin is converted by the body to Ampicillin.
• Hetacillin is a semisynthetic penicillin prodrug which itself has no antibacterial activity, but it is converted in the body to ampicillin and has actions and uses similar to ampicillin.
• Hetacillin is prepared by reacting ampicillin with acetone.
• Ampicillin may give a fake positive diagnostic test for Glucose.